Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the wordpress-seo domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/html/wp-includes/functions.php on line 6260 New Study Shows GliSODin Inhibits DNA Damage Due to Ischemia-reperfusion Induced Oxidative Stress - Nutraceuticals World

What are you searching for?

Sign in
Research

New Study Shows GliSODin Inhibits DNA Damage Due to Ischemia-reperfusion Induced Oxidative Stress

Author Image

By: Sean Moloughney

Editor, Nutraceuticals World

PL Thomas has released the results of a new study using its dietary supplement ingredient, GliSODin, which were recently presented at the 11th Congress of the European Shock Society in Vienna, Austria. The study was conducted by a team of researchers at the University of Ulm, Germany, and it looked at ischemia-reperfusion injury, which can be a concern during surgery, caused by the restriction and reintroduction of blood flow. The generation of oxygen-derived radicals has been demonstrated to be the major mechanism of ischemia-reperfusion induced oxidative damage. In this animal study, swine were given GliSODin or placebo, and DNA damage was evaluated in blood samples before and after hyperbaric-oxygen induced oxidative stress, using a measure of DNA strand breaks. The GliSODin group demonstrated significant DNA protection compared to placebo. DNA strand breaks were then used to evaluate DNA damage induced by ischemia-reperfusion. During thoracic aortic surgery, whole blood samples were taken before thoracic aortic cross-clamping, 30 minutes after clamping, and two and four hours after declamping. GliSODin reduced oxidative DNA damage related to surgical stress and ischemia-reperfusion after aortic clamping compared to placebo, resulting in a statistically significant difference two hours after declamping. Finally, isoprostane levels, another marker of oxidative stress, increased in both hepatic venous and portal venous samples of the placebo group, but not in the GliSODin group.

Add us as a preferred source on Google

Get the latest Nutraceuticals World news, insights and analysis in your Google Search and AI experiences.

Add Nutraceuticals World as a preferred source on Google (opens in a new tab)

Keep Up With Our Content. Subscribe To Nutraceuticals World Newsletters